MACSYS is honoured to present Prof Brenda Andrews, a globally recognised pioneer in large scale genetics & cell biology research.

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Title: Global mapping of genetic interactions in yeast and human cells reveals conserved principles of genetic networks.

Abstract: We used CRISPR-based screening to test ~4 million gene pairs for genetic interactions in the human HAP1 cell line, revealing functional relationships among ~3800 human genes. Comparison to our complete genetic interaction network for yeast revealed conservation of genetic network structure and topology.

🔗Billman et al 2026: https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4

Our Speaker: Professor Brenda Andrews is University Professor and Canada Research Chair in Systems Genetics and Cell Biology in the Donnelly Centre for Cellular and Biomolecular Research and the Department of Molecular Genetics at the University of Toronto.

Her lab has been at the forefront of research aimed at understanding cellular signalling processes and genetic networks in yeast using functional genomics, high content screening and gene expression tools. Her lab created the first complete genetic interaction map for a model eukaryotic cell.

Professor Andrews’ current work is linking genotype to phenotype by combining genetics and high content screening to assess changes in protein localization and abundance under a variety of genetic, environmental and chemical stresses using rapid image acquisition and analysis. Professor Andrews is a Companion of the Order of Canada, a Fellow of the Royal Society of Canada, a Fellow of the American Academy of Microbiology, and an International Member of the US National Academy of Sciences.

Seminar Chair: Professor Traude Beilharz, MACSYS Chief Investigator

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Joining this online event will also connect you to the MACSYS 2026 Annual Retreat, with this seminar launching the research section of this key MACSYS event.

Please note you must be registered for this event to receive the webinar link. The webinar link will be sent via calendar invite by the 14th October.

View the MACSYS Code of Conduct here https://macsys.org/about_macsys/code-of-conduct/