Many current computational biology efforts lack robust and comprehensive experimental inputs or validation. What sets us apart in MACSYS is our strong emphasis on integrating experimental studies into modelling.

To create reliable Whole Cell Models, it is crucial to thoroughly validate and refine their predictions through carefully designed and optimised experiments. That’s where our exceptional experimental team comes in. We have world-leading experts specializing in prokaryotic and eukaryotic microorganisms, along with cutting-edge capabilities for global quantitative analyses of cellular molecules across various physiologically relevant timeframes. This includes transcriptomics, proteomics, metabolomics, and lipidomics analyses, enabling us to understand the temporal dynamics and interactions of these molecules. We also have expertise in phenotypic assays and synthetic biology, rounding out our comprehensive approach.

By leveraging this wealth of knowledge and state-of-the-art techniques, we can precisely define the baseline parameters of cells and observe the changes induced by genetic or chemical perturbations. This iterative process allows us to continuously test, improve, and validate our WCMs and the methodologies used to create them.

By bridging the gap between mathematical modelling and experimental biology we will unlock new insights into the inner workings of cells, driving advancements in biotechnology.