Cheng Soon Ong

Associate Investigators

Associate Investigator

Cheng Soon Ong is the director of the Machine Learning and Artificial Intelligence Future Science Platform (MLAI FSP) at the Commonwealth Scientific and Industrial Research Organisation (CSIRO) and an adjunct Professor at the Australian National University.

The MLAI FSP is dedicated to enabling scientific discovery by harnessing the power of machine learning and artificial intelligence. It employs over 30 postdoctoral researchers and 10 mid-career researchers who work in cross disciplinary teams to achieve the aims and objectives of MLAI FSP. Among them is a team working on problems in digital agriculture and host pathogen responses, which uses genotype to phenotype models. Another team builds deep learning models of DNA sequences and develops MLAI models for designing gene regulation sequences. These designs are then biologically verified using synthetic biology in bacteria.

Additionally, Ong has had extensive experience in extending machine learning approaches for problems in computational biology, and is currently developing active learning, bandits, choice theory and adaptive experimental design methods.


Padmini Rangamani

Associate Investigators

Associate Investigator

Professor Padmini Rangamani’s research is focused on understanding the design principles of biological systems. 

Her long-term research goal is to understand the control of cell shape by analysing biological membranes and their interaction with proteins and the cytoskeleton using principles from transport phenomena. This is a unifying framework that brings together, mechanics of the membrane, membrane-bound proteins, and their coupled interactions. Her work uses a combination of novel mechanical theories and computational approaches to simulate many aspects of cellular membranes, in collaboration with experimentalists.


Douglas Pires

Associate Investigators

Associate Investigator

Associate Professor Douglas Pires is highly experienced in developing state-of-the-art machine learning applications for bioinformatics and cheminformatics to support and enhance biomedical and biological research.

He is particularly interested in using structural bioinformatics to understand how mutations can affect protein structure and function, leading to different phenotypes. He also has an outstanding track-record in developing machine learning applications for drug discovery and to leverage data at scale.


Charles Pence

Associate Investigators

Associate Investigator

Assistant Professor Charles Pence is an expert in the history and philosophy of biology and Director of the Centre de philosophie des sciences et sociétés at Université catholique de Louvain. He has expertise in problems related to chance and stochastic processes in evolution.

He has produced highly acclaimed books on the rise of quantitative methods in evolutionary theory. As Director of the Ethics Institute at Louisiana State University, he gained experience in exploring the wider social, societal and political relevance of teaching and researching evolutionary topics. He is a co-editor of the journal Philosophy, Theory, and Practice in Biology. He has an interest in computing and computer models, and the digital humanities.


Wallace Marshall

Associate Investigators

Associate Investigator

Professor Wallace Marshall is an engineer by background and has developed engineering perspectives on the analysis of cellular systems and dynamics.

He has a particular interest in the interplay between biochemical and cell-mechanical processes, and in the ways these processes affect cell fate decisions. He is the director of the Centre for Cellular Engineering at the University of California at San Francisco. In this role he has established one of the worldleading research centres considering how we can use models and engineering methods to understand cellular behaviour and control cellular function.

Professor Marshall’s pioneering work in driving convergence between the physical, mathematical, engineering and life-sciences extends to the development of outreach activities. Here he has collaborated with the Exploratorium in San Francisco, to develop displays that educate the general public on how we, as human beings, are shaped by both our genes and our environments and how our bodies trillions of cells work together to create a human self.


Jennifer Martin

Associate Investigators

Associate Investigator

Associate Professor Jen Martin (@scidocmartin) spent many years working as a field ecologist until she decided the most useful thing she could contribute as a scientist was to teach other scientists how to be effective and engaging communicators.

Jen founded and leads the University of Melbourne’s acclaimed Science Communication Teaching Program and is deeply committed to helping scientists develop the skills they need to be visible, make connections and have impact.

She also practises what she preaches: for 18 years she’s been talking about science each week on 3RRR radio, she writes for a variety of publications, hosts the Let’s Talk SciComm podcast and MCs events. Jen was named the 2019 Unsung Hero of Australian Science Communication, is Ambassador for The Wilderness Society’s Nature Book Week and is a member of the Homeward Bound Faculty, a global leadership program for women in STEMM.

Her first popular science book “Why am I like this? The science behind your weirdest thoughts and habits” was published in 2022.


Andrea Loettgers

Associate Investigators

Associate Investigator

Andrea Loettgers is a senior researcher in the ERC project Possible Life-The Philosophical Significance of Extending Biology at the University in Vienna. She holds a habilitation in philosophy of science from the University of Bern and a PhD in physics from the University of Göttingen.

From 2001 to 2011 she has been a Postdoc at the California Institute of Technology. At Caltech she held joint appointments in the humanities and the biology department to conduct and philosophical analyse laboratory observations in synthetic biology. During this time, she had been awarded with a grant from the Swiss National Science Foundation and the Alfred Sloan Foundation. From 2005-2006 she had been appointed as the Hixon-Riggs Visiting Professor for Science, Technology and Social Studies at Harvey Mudd College. After returning to Switzerland Loettgers has been awarded by an additional grant from the Swiss National Science Foundation for a project on synthetic biology at the University of Geneva. From 2016 to 2018 she was appointed as Bernoulli Fellow at the Center of Space and Habitability.

In her research Loettgers investigates modeling practices in physics and biology based on laboratory observations. A special interest concerns the development of organizational principles in biology and their transfer in-between biology and physics. She has published in: British Journal for the Philosophy of Science, Philosophy of Science, European Journal for Philosophy of Science, Studies in History and Philosophy of Science, Studies in History and Philosophy of Biological and Biomedical Sciences, and The Monist.


Tarja Knuuttila

Associate Investigators

Associate Investigator

Professor Tarja Knuuttila’s research concerns the epistemology of scientific modelling, the relation of scientific models to the real world, and the connection between simplicity and generality of models, with varied fields of application including ecology, economics, and engineering.

She has developed a particular interest in the relevance of mathematical in complex scenarios, including biology, but also the economy. She is the principal investigator of the Possible Life project of the European Research Council, which studies the philosophy of hypothetical types of biochemistry including synthetic biology and astrobiology. In 2021 she was elected to the Academia Europaea.


Stuart Johnston

Associate Investigators

Associate Investigator

Dr Stuart Johnston is a mathematical biologist who focuses on multiscale modelling of migration processes. He has experience in modelling cellular behaviour, as well as the motion of individuals and animals. He regularly connects his models with experimental data to generate new biological insight.

Dr Johnston has developed mathematical models of the interactions between nanoparticles and cells, to understand and design future medical treatment delivery options. In 2020, he commenced an ARC Discovery Early Career Research Award Fellowship to study the ability of organisms to navigate through environments in the presence of uncertainty and noise, with a focus on cell transport and whale migration. He is currently a Lecturer in Applied Mathematics in the School of Mathematics and Statistics.


Wolfgang Huber

Associate Investigators

Associate Investigator

Dr Wolfgang Huber is an expert in bioinformatics, computational biology and machine learning/AI.

Huber works at the forefront of statistical bioinformatics research. He is one of the lead-developers and founders of Bioconductor. He is a research group leader and senior scientist at EMBL. He is a co-director of the Molecular Medicine Partnership Unit of EMBL and the Medical Faculty of the University of Heidelberg. He also co-directs EMBL’s “Theory” transversal theme.

His group develops statistical data analysis and machine learning methods for modern biotechnologies. He applies them to do discovery science across different domains of biology and biomedicine. He then translates these methods and ideas into reusable tools by engaging in open source software communities.